sirt1 activator srt1720 Search Results


sirt1 activator srt1720  (Euromedex)
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Euromedex sirt1 activator srt1720
ER stress in B12-deficient cells stems from <t>SIRT1</t> decreased expression. The levels of SIRT1 protein and transcript are lower in TO than in OT cells, respectively. Supplement with either B12 or SAM significantly increases SIRT1 level in TO cells ( P <0.001) ( a ). Modulation of the activity of SIRT1 via either an activator <t>(SRT1720,</t> denoted as SRT here) in TO cells or an inhibitor (EX527, denoted as EX here) in OT cells alters the expression of ER stress markers: SRT in TO cells increases BiP expression and attenuates ATF4 and CHOP expression ( P <0.05, P <0.01 and P <0.01, respectively) ( b ); EX in OT cells decreases BiP expression and leads to increased ATF4 and CHOP expression ( P <0.01, P <0.01 and P <0.05, respectively) ( b ). Reduced SIRT1 expression in control OT cells using two different siRNA against SIRT1 ( P <0.001); both leads to decreased HSF1 and BiP expression ( P <0.01 and P <0.01), as well as increased p-IRE1 α and p-PERK expression ( P <0.05 and P <0.05) ( c ). Data were compared by one-way ANOVA with Fisher's test, with n =8 in each group, and presented as means±S.D. (* P <0.05; ** P <0.01; *** P <0.001)
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ER stress in B12-deficient cells stems from SIRT1 decreased expression. The levels of SIRT1 protein and transcript are lower in TO than in OT cells, respectively. Supplement with either B12 or SAM significantly increases SIRT1 level in TO cells ( P <0.001) ( a ). Modulation of the activity of SIRT1 via either an activator (SRT1720, denoted as SRT here) in TO cells or an inhibitor (EX527, denoted as EX here) in OT cells alters the expression of ER stress markers: SRT in TO cells increases BiP expression and attenuates ATF4 and CHOP expression ( P <0.05, P <0.01 and P <0.01, respectively) ( b ); EX in OT cells decreases BiP expression and leads to increased ATF4 and CHOP expression ( P <0.01, P <0.01 and P <0.05, respectively) ( b ). Reduced SIRT1 expression in control OT cells using two different siRNA against SIRT1 ( P <0.001); both leads to decreased HSF1 and BiP expression ( P <0.01 and P <0.01), as well as increased p-IRE1 α and p-PERK expression ( P <0.05 and P <0.05) ( c ). Data were compared by one-way ANOVA with Fisher's test, with n =8 in each group, and presented as means±S.D. (* P <0.05; ** P <0.01; *** P <0.001)

Journal: Cell Death & Disease

Article Title: Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1

doi: 10.1038/cddis.2013.69

Figure Lengend Snippet: ER stress in B12-deficient cells stems from SIRT1 decreased expression. The levels of SIRT1 protein and transcript are lower in TO than in OT cells, respectively. Supplement with either B12 or SAM significantly increases SIRT1 level in TO cells ( P <0.001) ( a ). Modulation of the activity of SIRT1 via either an activator (SRT1720, denoted as SRT here) in TO cells or an inhibitor (EX527, denoted as EX here) in OT cells alters the expression of ER stress markers: SRT in TO cells increases BiP expression and attenuates ATF4 and CHOP expression ( P <0.05, P <0.01 and P <0.01, respectively) ( b ); EX in OT cells decreases BiP expression and leads to increased ATF4 and CHOP expression ( P <0.01, P <0.01 and P <0.05, respectively) ( b ). Reduced SIRT1 expression in control OT cells using two different siRNA against SIRT1 ( P <0.001); both leads to decreased HSF1 and BiP expression ( P <0.01 and P <0.01), as well as increased p-IRE1 α and p-PERK expression ( P <0.05 and P <0.05) ( c ). Data were compared by one-way ANOVA with Fisher's test, with n =8 in each group, and presented as means±S.D. (* P <0.05; ** P <0.01; *** P <0.001)

Article Snippet: SIRT1 activator SRT1720 was obtained from Euromedex (Strasbourg, France).

Techniques: Expressing, Activity Assay, Control

The effect of the activator and inhibitor of SIRT1 on the expression of ER stress markers is modulated by vitamin B12 in TO and OT cells. SIRT1 inhibitor, EX527, reduces the SIRT1 protein expression in both cell types ( P <0.01) and B12 supplement reverses its effects on ER stress transducers, including P-PERK ( P <0.05) and P-IRE1 α ( P <0.05 for all comparisons). B12 reverses also the expression of BiP after EX527 treatment in TO and OT cells ( P <0.05 for both cell types). Data were compared by one-way ANOVA with Fisher's test, with n =8 in each group, and presented as means±S.E. (* P <0.05 and ** P <0.01)

Journal: Cell Death & Disease

Article Title: Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1

doi: 10.1038/cddis.2013.69

Figure Lengend Snippet: The effect of the activator and inhibitor of SIRT1 on the expression of ER stress markers is modulated by vitamin B12 in TO and OT cells. SIRT1 inhibitor, EX527, reduces the SIRT1 protein expression in both cell types ( P <0.01) and B12 supplement reverses its effects on ER stress transducers, including P-PERK ( P <0.05) and P-IRE1 α ( P <0.05 for all comparisons). B12 reverses also the expression of BiP after EX527 treatment in TO and OT cells ( P <0.05 for both cell types). Data were compared by one-way ANOVA with Fisher's test, with n =8 in each group, and presented as means±S.E. (* P <0.05 and ** P <0.01)

Article Snippet: SIRT1 activator SRT1720 was obtained from Euromedex (Strasbourg, France).

Techniques: Expressing

The reduced SIRT1 expression is homocysteine-independent and methylation-dependent. ( a ) SIRT1 expression increases after homocysteine treatment in both TO and OT cells ( P <0.05 for both), whereas P-PERK activation is reduced in TO cells ( P <0.05). ( b ) AdoX treatment in OT cells increases the protein expression of HIC1 ( P <0.05) and decreases the expression of SIRT1, HSF1 and BiP. It increases the expression of the two ER stress transducers, P-IRE1 α and P-PERK ( P <0.05 in both cell types). ( c ) Influence of SAM, vitamin B12 and the methyltransferase inhibitor AdoX on the relative abundance of SIRT1 and HIC1 transcripts in TO and OT cells. AdoX increases significantly the relative abundance of HIC1 transcript in TO cells ( P <0.001), which can be partially reversed by the addition of either SAM ( P <0.01) or B12 ( P <0.001). These same changes occur also in the control OT cells (upper panel). Inversely, AdoX treatment decreases the relative abundance of SIRT1 transcript in control OT cells only, and the addition of either SAM or B12 reverse this reduction in SIRT1 transcript ( P <0.05 for both comparisons) (lower panel). Data were compared by one-way ANOVA)with Fisher's test, with n =8 in each group, and presented as means±S.E. (* P <0.05; ** P <0.01 and *** P <0.001)

Journal: Cell Death & Disease

Article Title: Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1

doi: 10.1038/cddis.2013.69

Figure Lengend Snippet: The reduced SIRT1 expression is homocysteine-independent and methylation-dependent. ( a ) SIRT1 expression increases after homocysteine treatment in both TO and OT cells ( P <0.05 for both), whereas P-PERK activation is reduced in TO cells ( P <0.05). ( b ) AdoX treatment in OT cells increases the protein expression of HIC1 ( P <0.05) and decreases the expression of SIRT1, HSF1 and BiP. It increases the expression of the two ER stress transducers, P-IRE1 α and P-PERK ( P <0.05 in both cell types). ( c ) Influence of SAM, vitamin B12 and the methyltransferase inhibitor AdoX on the relative abundance of SIRT1 and HIC1 transcripts in TO and OT cells. AdoX increases significantly the relative abundance of HIC1 transcript in TO cells ( P <0.001), which can be partially reversed by the addition of either SAM ( P <0.01) or B12 ( P <0.001). These same changes occur also in the control OT cells (upper panel). Inversely, AdoX treatment decreases the relative abundance of SIRT1 transcript in control OT cells only, and the addition of either SAM or B12 reverse this reduction in SIRT1 transcript ( P <0.05 for both comparisons) (lower panel). Data were compared by one-way ANOVA)with Fisher's test, with n =8 in each group, and presented as means±S.E. (* P <0.05; ** P <0.01 and *** P <0.001)

Article Snippet: SIRT1 activator SRT1720 was obtained from Euromedex (Strasbourg, France).

Techniques: Expressing, Methylation, Activation Assay, Control